Family 2 - Support-bound oligonucleotides (WO90/03382)

These patents describe the use of a covalent phosphodiester link for attaching nucleic acids to solid supports. The link is easy to synthesise and is stable under de-protection conditions. The link is formed between a terminal phosphate group of a nucleoside and a hydroxyl group on the surface so that it does not disrupt any hybridisation reactions.

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