DMD Array (4x44k)

About Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is an X-linked (Xp21) condition affecting ~1 in 3,000 male births
Deletions and duplications within the DMD gene account for 60—70% of all mutations
The DMD gene is large (2.4 Mb) and consists of 79 exons which makes accurate detection of deletions and duplications challenging using currently available non-array methods

CytoSure DMD array is a 4x44k feature oligonucleotide microarray providing comprehensive coverage of the entire DMD gene in a single assay
The DMD array can also be used to investigate deletions and duplications associated with Becker’s Muscular Dystrophy (BMD). The incidence of BMD is 3 to 6 in 100,000 male births
The array features an average probe spacing of 10bp within exons and 106 bp within introns

Detection of a 4kb deletion within the DMD gene

Detection of a 4kb deletion within the DMD gene.

(Data courtesy of Emory Genetics Laboratory)

Detection of an 85kb duplication within the DMD gene.

(Data courtesy of Emory Genetics Laboratory)

High-density probe spacing enables comprehensive coverage of the entire DMD gene on one array permitting accurate determination of deletions and duplications
Simple workflow with minimal sample handling gives you increased confidence and peace of mind
60mer oligonucleotide probes offer high specificity, sensitivity and reproducibility for high quality data
High-quality design (in collaboration with Emory Genetics Laboratory), together with Agilent manufactured slides and empirical testing and optimisation of extensive probe sets, ensures confidence in the quality of array design and performance
Four samples per slide minimises cost-per sample and reduces variability

Product	Contents	Cat. No
DMD (4x44k)	Microarray with four arrays of 44,000 spots; CytoSure Interpret analysis software	020023

CytoSure™ products are for research use only