New CytoSure™ ISCA +SNP array for accurate detection of CNV and LOH
Oxford Gene Technology (OGT), provider of innovative genetics research and biomarker solutions to advance molecular medicine, has today released the latest addition to its range of CytoSure™ ISCA microarrays for reliable and standardised genomic aberration detection. The new patent pending CytoSure ISCA +SNP (4x180k) array combines array comparative genomic hybridisation (aCGH) probes, endorsed by the International Standards for Cytogenomic Arrays (ISCA) Consortium, with fully validated single nucleotide polymorphism (SNP) content. This allows the accurate and cost-effective detection of copy number changes and loss of heterozygosity (LOH) using a single array. As the newest member of the CytoSure ISCA array portfolio, the CytoSure™ ISCA +SNP array includes enhanced SNP coverage for high-resolution LOH detection. This means that the analysis of genetically complex samples from related individuals is now even more accurate and in-depth, while integration with OGT’s powerful and intuitive CytoSure Interpret Software ensures that analysis is easy, fast and insightful.
James Clough, Vice President Clinical and Genomic Solutions at OGT, commented: “For several years, OGT has worked closely with ISCA to design a range of arrays focused on providing standardised, evidence-based content. The latest CytoSure ISCA +SNP design is part of our ongoing commitment to further enhancing the accuracy, reproducibility and efficiency of genomic analysis using microarrays, by creating powerful, multi-feature arrays that generate as much relevant data as possible.”
Although aCGH is the gold standard for detecting copy number variation (CNV), until recently it was not possible to combine this technique with LOH and uniparental disomy (UPD) detection using SNP probes. This meant that either two separate arrays were needed, or that inferior SNP-based CNV detection platforms were used. To solve this problem, the CytoSure ISCA +SNP array allows CNV and SNP detection to be carried out on a single array, using optimised probes that are fit for each purpose. By allowing both methods to work efficiently under standard CytoSure aCGH hybridisation conditions, these arrays fit seamlessly into existing workflows. To provide as much relevant information as possible, the arrays include content specifically designed to focus on disease and syndrome-associated regions, in addition to offering whole genome ‘backbone’ coverage.
To simplify the analysis of samples such as those suspected of exhibiting UPD, OGT provides all users of CytoSure arrays with its industry-leading CytoSure Interpret Software. With various innovative features, the software maximises the ease, consistency and speed of data interpretation, while minimising the need for user intervention. The results provided include extensive annotation tracks covering syndromes, genes, exons, CNVs and recombination hotspots, while links to publicly available databases put results into context. Using the comprehensive range of CytoSure products, the transition from sample to biological insight is always fast, accurate and reliable.
For further information, please contact:
Oxford Gene Technology, Begbroke Science Park, Sandy Lane, Yarnton, Oxford OX5 1PF, U.K.
T: +44 (0) 1865 856826 ; F: +44 (0) 1865 848684 ; E: products@ogt.co.uk
W: www.ogt.co.uk ; Twitter: @OxfordGeneTech
Notes for editors:
About Oxford Gene Technology
Founded by Professor Ed Southern, Oxford Gene Technology (OGT) provides innovative genetics research and biomarker solutions to advance molecular medicine. The company has two trading businesses: Genomics comprises of CytoSure™ cytogenetics array, labelling and interpretation software products and services for the detection of chromosomal abnormalities, and Genefficiency™ Genomic Services, a unique combination of platforms, expertise and processing capabilities to deliver rapid, relevant genomic data. The Biomarkers business utilises proprietary next generation technologies to build a rich patent-protected portfolio of promising biomarkers for early stage cancer detection including advanced programmes in colorectal and prostate cancer plus the autoimmune disease systemic lupus erythematosus.
CytoSure™ and Genefficiency™ NGS browser: For Research Use Only; Not for Use in Diagnostic Procedures
CytoSure: This product is provided under an agreement between Agilent Technologies, Inc., and OGT. The manufacture, use, sale or import of this product may be subject to one or more of U.S. patents, pending applications, and corresponding international equivalents, owned by Agilent Technologies, Inc. The purchaser has the non-transferable right to use and consume the product for RESEARCH USE ONLY AND NOT for DIAGNOSTICS PROCEDURES. It is not intended for use, and should not be used, for the diagnosis, prevention, monitoring, treatment or alleviation of any disease or condition, or for the investigation of any physiological process, in any identifiable human, or for any other medical purpose.
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