Patents
Oxford Gene Technology: Patent Portfolio
OGT has a large number of patent families covering
areas that are relevant to the biological sciences such as microarrays,
genomics and electrochemistry.
Some of the patent families actively out-licensed by OGT are detailed below
Family 1 - Analysing polynucleotide
sequences
PCT/GB89/00460 WO89/10977
This patent family covers oligonucleotide microarrays, their manufacture and
their use for the analysis of polynucleotide sequences. These fundamental patents
are also referred to as the “Southern Array Patents”
Family 2 - Support-bound
oligonucleotides
PCT/GB89/01114 WO90/03382
These patents describe the use of a covalent phosphodiester link for attaching
nucleic acids to solid supports. The link is easy to synthesise and is stable
under de-protection conditions. The link is formed between a terminal phosphate
group of a nucleoside and a hydroxyl group on the surface so that it does not
disrupt any hybridisation reactions.
Family 3 - Electropatterning
of surfaces
PCT/GB93/00857 WO93/22480
These patents describe the use of electrochemistry to create microarrays; in
particular using electrode technology to treat a region of a surface and synthesise
oligomers, specifically oligonucleotides on a surface.
Family 6 - Detecting sequence variations
PCT/GB96/00848 WO96/31622
The patents in this family describe the use of microarray technology to detect
variations in DNA sequences e.g. SNPs or different lengths of tandem repeat
regions. Target nucleic acids hybridise to probes on an array and are extended
through ligation or chain extension to detect variations.
Family 8 - Common Cathode for Electrochemistry
PCT/GB2004/004390 WO2005/037425
This family describes applications for a method for electrochemically treating
or modifying a substrate using a device which has a common first electrode.
This method is suitable for generating patterns of oligonucleotides bound to
a solid surface or for making devices on printed circuit boards.
Family 11 - Treatment of Substrates using an Electrochemical Method
PCT/GB02/003992 WO03/020415
This application describes the use of electrodes to generate an active redox
product which can modify an adjacent surface, suitable for the step-wise chemical
synthesis of oligomers such as oligonucleotides on a surface. Diffusion of
the redox product within the electrolyte is controlled by quenching with a
second redox product generated by a different electrode.
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