CytoSure™ Aneuploidy Array

Spontaneous abortions are relatively common and often caused by chromosomal abnormalities, particularly trisomies, with many occurring in early pregnancy. The CytoSure Aneuploidy array has been developed in collaboration with Professor Joris Vermeesch, Head of the Laboratory for Cytogenetics and Genome Research in Leuven. It allows the straightforward detection of aneuploidy in miscarriage samples and a faster turnaround time than traditional methods — delivering results in 2–3 days.

The CytoSure Aneuploidy array enables:

• Simple, reliable and cost-effective detection of chromosomal imbalances
• Greater chance of identifying causative imbalances
• Faster access to results

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Simple, reliable and cost-effective detection of chromosomal imbalances

CytoSure Interpret Software, which accompanies all CytoSure arrays, allows rapid and automated detection chromosomal imbalances. The optimised 8 x 15k slide format ensures fast and cost-effective analysis. The clear and intuitive layout allows you to view chromosomes of interest at a glance.

Figure 1:  Easy identification of chromosomal imbalances. The Aneuploidy Summary panel displays a box and whisker plot. The centre of each ‘box’ represents the average log ratio of all of the probes on that chromosome. In this example one copy of chromosome 18 has been gained. A gain or loss of a whole chromosome would shift the mean and the upper and lower quartiles of the box and whisker plot.

Enlarge this image (PDF)

Greater chance of identifying causative imbalances

Routine analysis of miscarriage samples has traditionally been restricted to karyotyping with the associated limitations caused by the need to prepare cell cultures. Cell culture is not required for aCGH. The optimised probe set allows confident genome-wide aberration detection. Using the CytoSure Anueploidy array it is possible to analyse more than just whole chromosome gains and losses, you can also detect smaller aberrations with a detection limit of around 250kb. In addition, mosaic samples are also easier to identify. 

Faster access to results

Identifying chromosomal imbalances using karyotyping requires cell culture, meaning the whole process can take up to a week. Using the CytoSure Aneuploidy array, it is now possible to accurately identify chromosomal imbalances in just 2–3 days.

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* This array is intended solely for the identification of aneuploidy in miscarriage samples and is not designed to be used on amplified DNA samples.

CytoSure™ products are for research use only.

View CytoSure Aneuploidy data (PDF)

^† Poster kindly provided by Professor Joris Vermeesch, Head of the Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, University of Leuven, Leuven.