CytoSure™ Syndrome Plus v2 Array

CytoSure™ Syndrome Plus v2 Arrays deliver:

• Extensive genome coverage
• Enhanced detection of chromosomal abnormalities
• High-resolution coverage of clinically relevant regions
• Effortless data interpretation

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Extensive genome coverage

OGT offers a combination of high resolution arrays, labelling kits and analysis software that together provide a unique, comprehensive solution for cytogeneticists.

The CytoSure Syndrome Plus v2 Array, developed in close collaboration with leading cytogeneticists, provides superior coverage of cytogenetic syndromes and accurate whole genome aberration detection. Comprised of 2 x 105,000 oligonucleotide features, this array allows parallel high-resolution detection of DNA aberrations in 2 samples.

The CytoSure Syndrome Plus v2 Array focuses on:

• 85 constitutional syndromes, including Angelman, DiGeorge, Cri du Chat etc.
• Sub-telomere regions to 5Mb
• Recombination hotspots surrounded by segmental duplications

A full list of genetic disorders detected by CytoSure Syndrome Plus v2 Array is available here.

High-resolution coverage of clinically relevant regions

Enhanced detection of chromosomal abnormalities

Each syndrome-related aberration is targeted by multiple specific probes, allowing accurate detection of copy number variations (CNVs). The probes for this array have been selected from OGT’s proprietary Oligome™ database — a database of over 23 million in silico optimised oligonucleotide probes. CytoSure arrays utilise 60 mer oligonucleotide probes, which have been shown to offer higher signal-to-noise ratios through increased specificity and sensitivity.

Effortless data interpretation 

All CytoSure arrays are provided with our complimentary, industry-leading CytoSure Interpret Software — a powerful, easy-to-use package for the analysis of aCGH data (Figure 1). Innovative features such as the Accelerate Workflow enable standardised and automated data analysis. In addition, extensive annotation tracks covering syndromes, genes, exons, CNV and recombination hotspots — each of which link to publicly available databases — provide results in context.

Figure 1. CytoSure Syndrome Plus v2 Array data showing deletions on a) chromosome 9 and b) chromosome 15.

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Related products

CytoSure™ products are for research use only.