For accurate detection of all types of genetic aberrations, various technologies are required. By combining information from multiple technologies, researchers can analyse complex samples and get the most complete overview of disease-driving mutations.
OGT offers an integrated portfolio of products providing clinical researchers with the most advanced tools available to study haematological disorders, including CytoCell® fluorescence in-situ hybridisation (FISH) probes and myProbes® custom FISH probes, SureSeq™ next generation sequencing (NGS) panels and myPanel™ custom panels, and CytoSure® array products and custom arrays.
Our products are backed by deep technical expertise and dedicated customer support.
Myeloid malignancies are a heterogeneous group of diseases, associated with a wide range of variants ranging from mutations to structural variations. The panel accurately detects SNVs and indels in genes such as CEBPA, JAK2, CALR and MPL, as well as structural variants including FLT3-ITDs and KMT2A-PTDs, and is able to detect low-frequency SNVs and indels with confidence. The figure (above) shows a PTD detection spanning exons 2-8 of the KMT2A gene.
View ProductDesigned in collaboration with recognised cancer experts to detect 13 key genes and 5 chromosomal regions implicated in CLL progression. The figure (above) compares SureSeq CLL + CNV Panel data with array data for a 42.7Mb deletion of 11q covering ATM (top) and a 0.6Mb biallelic loss called within a larger ~1Mb single allele deletion in the region covering DLEU2/DLEU1/DLEU7 on chromosome 13q (bottom).
View ProductThe Del(5q) Plus Tri-Colour Deletion Probe mix consists of three distinct probes. The green probe (378kb) covers the CDC25C and EGR1 genes, along with their flanking regions that include the RH68817 and D5S500 markers. The red probe set (147kb, 155kb and 189kb) locates between the D5S1708 and D5S551 markers and includes the CSF1R, PDGFRB, TCOF1 and RPS14 genes. The aqua probe set (224kb and 367kb) locates between the markers RH76617 and RH92681 and includes the genes TERT, CLPTM1L, SLC6A3 and SDHAP3.
View ProductThe CBFB Breakapart Probe mix consists of two distinct probes. The red probe (292kb) is centromeric to the CBFB gene and extends beyond the RH104363 marker to cover part of the DYNC1LI2 gene and includes the markers SHGC-60620 and SHGC-58067. The green probe (309kb) is telomeric to the CBFB gene and extends through the marker RH78922 beyond the ZDHHC1 gene to a region telomeric to the marker RH11782.
View ProductOGT’s range of CytoSure® Cancer +SNP arrays combine long-oligo probes for superior copy number variant (CNV) detection alongside single nucleotide polymorphism (SNP) probes – which function using OGT proprietary technology – for accurate identification of loss-of-heterozygosity (LOH). The figure (above) shows a schematic of OGT’s unique SNP probe technology, allowing the use of any reference sample with no restriction digest.
View ProductBenefit from OGT’s extensive array design expertise to produce an array matching your precise specifications. These arrays are ideal if you want to know the precise coordinates of an aberration by analysing specific areas of the genome at high resolution. The figure (above) shows how our custom arrays can be designed in a variety of formats depending on your desired level of focus, with 1, 2, 4, or 8 arrays available per slide to provide the most cost-effective solution for your research.
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